Effect of the Combination of Nitrate and Caffeine on Critical Power In Trained Male Cyclists

Completed · Not applicable · Has a placebo group

Conditions studied: Exercise Performance of Fit Athletes, Exercise Performance, Cycling Performance

In brief

This study is investigating the independent and combined effects of acute dietary nitrate and caffeine supplementation on performance during a 3-minute all-out cycling test in trained male cyclists. In a randomized, double-blind, placebo-controlled, crossover design, participants will complete four experimental conditions: nitrate, caffeine, nitrate plus caffeine, and placebo. Primary outcomes include end power (EP) and work done above end power (WEP), surrogate measures of critical power and W'. The study aims to determine whether combined supplementation provides additive benefits for severe-intensity exercise performance.

Key facts

Study ID

NCT07501806

Run by

Lindenwood University

People needed

15

Starts

2020-11-17

Expected to finish

2021-11-11

Last updated by the study team

2026-03-30

Who can join

Age: 18 and older, up to 40. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Males between the ages of 18 and 40 years of age
• All participants must be trained cyclists, having participated in structured cycling training consisting of at least 2-3 sessions per week for at least 30-60 min each session during the past 12 months.
• All participants must possess a relative max power output (Wmax) of 4.0 W/kg or greater OR a maximal oxygen consumption (VO2max) of 50 ml/kg/min.
• All participants must be healthy and free of any disease as determined through the completion of a medical history questionnaire.
• Body mass index (BMI) between 18.5 - 30 kg/m\^2 OR bodyfat percentage <30%

You may not qualify if…

• All females
• Males who are younger than 18 years and older than 40 years of age
• Individuals who have a VO2max below 50 ml/kg/min and a relative Wmax below 4.0 W/kg
• Individuals who fail to meet the minimum training requirements of 2-3 sessions per week of structured cycling training for at least 30-60 min per session during the past 12 months.
• Any individual currently diagnosed with or being treated for any cardiovascular, renal, pulmonary, orthopedic, immunological, psychological or musculoskeletal disorder.
• Any individual who is currently supplementing with a known or purported ergogenic aid (nitrates, caffeine, beta-alanine, bicarbonate, creative, Cordyceps) will be required to refrain from their use for 30 days before beginning the study.
• Individuals who regularly smoke or have quit smoking within the last 6 months.

Where it is running

• Exercise and Performance Nutrition Laboratory — Saint Charles, Missouri, United States

Full record on ClinicalTrials.gov

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