Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice

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Conditions studied: Basal Cell Carcinoma of Skin, Optical Coherence Tomography (OCT), Neoplasms, Neoplasms, Basal Cell, Carcinoma, Basal Cell (BCC), Real-world Study, Implementation

In brief

Basal cell carcinoma (BCC) is the most common skin cancer in the Netherlands, with incidence rates continuing to rise. The current diagnostic standard combines clinical evaluation and dermoscopy, while biopsy followed by histopathological examination remains the gold standard when uncertainty about the diagnosis persists. However, biopsy is invasive, time-consuming, and costly. Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive imaging technique that has emerged as a promising alternative to biopsy for BCC suspected lesions. This retrospective study aims to evaluate the real-world clinical performance of LC-OCT in routine dermatological practice, where it has been integrated into the diagnostic work-up for BCC-suspect lesions.

Key facts

Study ID

NCT07501780

Run by

Maastricht University Medical Center

People needed

297

Starts

2026-03-15

Expected to finish

2027-12-01

Last updated by the study team

2026-03-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged ≥18 years
• LC-OCT performed as part of diagnostic evaluation between January 2025 and June 2025 at Mohs clinics in the Netherlands
• Histopathological results (biopsy or excision) and/or 6-12 month clinical follow-up data available

You may not qualify if…

• Patients <18 years of age
• Cases without histopathological confirmation or available follow-up data

Where it is running

• Maastricht University Medical Center + — Maastricht, Limburg, Netherlands

Full record on ClinicalTrials.gov

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