Hyaluronic Acid in Endodontic Microsurgery

Recruiting now · Not applicable

Conditions studied: Periapical Periodontitis

In brief

This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first molars. Participants previously treated with non-surgical endodontic therapy will be allocated to either endodontic microsurgery with cross-linked hyaluronic acid application (test group) or the same surgical procedure without adjunctive material (control group), with 12 months of follow-up. The study hypothesis is that cross-linked hyaluronic acid improves soft- and hard-tissue healing, reduces postoperative inflammation and pain, and supports more stable surgical outcomes. Primary outcomes include early soft tissue healing (Early Wound Healing Score, day 4) and postoperative pain (visual analogue scale). Secondary outcomes include periapical healing assessed by blinded evaluators on periapical radiographs (Molven criteria) at 3, 6, and 12 months, and on CBCT scans (PENN 3D criteria) at 6 and 12 months, as well as cortical plate healing (RAC/B index). This study aims to provide clinical evidence on the potential regenerative and anti-inflammatory benefits of cross-linked hyaluronic acid in endodontic microsurgery.

Key facts

Study ID

NCT07501585

Run by

University of Bern

People needed

46

Starts

2026-02-20

Expected to finish

2028-12-31

Last updated by the study team

2026-03-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Written informed consent
• ≥18 years of age
• Apical peridontitis at maxillar or mandibular first molars ≥ 12 months after non-surgical endodontical treatment
• Full mouth plaque score (FMPS) and bleeding score (BoP) < or 20%
• Periapical lesion < or 10 mm
• Four-wall bone defect morphology

You may not qualify if…

• Smokers of more than 10 cigarettes a day
• Allergy to hyaluronic acid
• Pregnancy or lactation
• Uncontrolled Diabetes
• Untreated periodontal conditions
• Any conditions associated with poor compliance or failure to maintain good oral hygiene
• Acute infections lesions in areas intended for surgery
• Chemotherapy and radiotherapy treatment

Where it is running

• Praktika 1 — Moscow, Russia (enrolling)

Full record on ClinicalTrials.gov

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