Menopause Effects on Cortico-reticular Functioning

Recruiting now · Not applicable

Conditions studied: Menopause, Hormone Replacement Therapy

In brief

Post-menopausal women who request to begin hormone-replacement therapy (HRT) are directed to the research team. The participants are tested before beginning HRT, after two months of HRT, and five months of HRT. Tests include strength performance, central nervous system functioning, body composition, resting metabolic rate, and vascular screening. The participants are provided a 12-week training intervention (2 x strength, 2 x endurance per week) that can be voluntarily followed between tests at month 2 and 5. Compliance with the training program is recorded. A minimum of 15 participants are needed a priori, but the investigators aim to recruit and test 20 women.

Key facts

Study ID

NCT07500922

Run by

University of Jyvaskyla

People needed

20

Starts

2026-04-25

Expected to finish

2028-03-31

Last updated by the study team

2026-05-01

Who can join

Age: 50 and older, up to 59. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• at least 6 months since their last period but no more than being 5 years post-menopausal
• basal follicular-stimulating hormone concentration > 30 IU/L (confirmed post-recruitment)
• willing to start combined hormonal treatment
• womb and ovaries intact with normal functioning throughout reproductive age
• willing to provide informed consent
• does not have any of the exclusion criteria for TMS measurements according to Rossi et al. (2021 Clin Neurophysiol. 132(1):269-306.) (i.e. arterial hypertension, heart attack/seizure history, migraine, pacemaker or cochlear implant or other implanted metal/electronic device)

You may not qualify if…

• classified as excessively obese via BMI assessment (i.e., >35 kg/m2)
• intra-uterine device usage during transition to menopause
• cardiovascular or skeletomuscular disease preventing strenuous physical activity
• smoker
• diagnosed psychiatric illness
• epilepsy
• other diagnosed injuries/illness affecting the neuromuscular system

Where it is running

• University of Jyväskylä — Jyväskylä, Finland (enrolling)

Full record on ClinicalTrials.gov

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