Study of the Role of Top-down Processes in Neuronal Reorganization and Recovery From Sensory Loss: an Exploratory Behavioral and Electroencephalographic Study in Cochlear-supported Deaf Patients
Starting soon
Conditions studied: Deafness, Bilateral
In brief
This study posits that central top-down processes (attention, inhibition), marked by alpha oscillations in EEG, play a key role. Understanding the evolution of these neuronal signatures and their link to pre-implantation visual dependence could allow the identification of biomarkers predictive of the success of auditory rehabilitation.
Key facts
- Study ID
- NCT07500909
- Run by
- University Hospital, Toulouse
- People needed
- 90
- Starts
- 2026-03-01
- Expected to finish
- 2029-03-01
- Last updated by the study team
- 2026-03-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For cochlear implant patients:
- Adult patients
- Profound bilateral hearing loss requiring a first cochlear implant
- Normal cochlear anatomy (confirmed by preoperative imaging)
- Full insertion of the cochlear electrode array planned
- Acceptance of the protocol and signing of the informed consent form
- Enrollment in a social security or equivalent plan
- For young patients with normal hearing:
- Adult patients aged 18 to 40
- Normal and symmetrical hearing
- Acceptance of the protocol and signature of the informed consent form
- Affiliation with a social security scheme or equivalent
- For older patients with normal hearing:
- Patients over 50 years of age, matched by gender and age (+/- 2 years) with the cochlear implant patient group
- Normal and symmetrical hearing, with hearing thresholds < 20 dB HL at 2 kHz and < 40 dB HL at 4 kHz
- Acceptance of the protocol and signature of the informed consent form
- Affiliation with a social security scheme or equivalent
- For experienced cochlear implant recipients:
- Adult patients.
- Unilateral cochlear implant activated for 1 year or more.
- Disyllabic word recognition score at 60 dB in free field of 70% or higher.
- Acceptance of the protocol and signature of the informed consent form.
- Affiliation with a social security plan or equivalent.
- For severely deaf patients fitted with hearing aids:
- Adult patients.
You may not qualify if…
- History of associated neurological pathology
- Etiologies with unfavorable prognoses, such as recurrent chronic otitis media: These conditions are associated with a poor prognosis due to chronic inflammation that can affect the cochlea
- Duration of profound bilateral deafness exceeding 5 years (worse prognosis)
- Contraindications to EEG or other neurophysiological examinations within the study (for all groups)
- Cognitive impairment confirmed by the MOCA test for the cochlear implant patient group and the group of elderly subjects with normal hearing
- Use of psychotropic medications that may interfere with the results of cognitive or neurological tests
- History of epilepsy or other major neurological disorders
- Pregnancy or breastfeeding
- Participation in another interventional research protocol or one that impacts the criteria studied in this project
- Individuals under legal guardianship (guardianship, tutorship, curatorship, institutionalized, or under a future protection mandate)
Full record on ClinicalTrials.gov
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