Effect of Morus Nigra Mouthwash on Gingivitis Treatment

Recruiting now · Not applicable

Conditions studied: Gingivitis

In brief

The aim of this study is to evaluate the clinical, microbiological, and biochemical effects of Morus nigra (black mulberry) mouthwash when used as an adjunct to non-surgical periodontal treatment (scaling and root planing - SRP) in patients with generalized gingivitis. Participants will be randomly assigned to two groups: one receiving SRP only, and the other receiving SRP plus Morus nigra mouthwash twice daily for 14 days. Clinical parameters, cytokine levels in gingival crevicular fluid (TNF-alpha, IL-1beta, IL-10), and subgingival bacterial load will be assessed at baseline, 1 month, and 3 months.

Key facts

Study ID

NCT07499596

Run by

Inonu University

People needed

30

Starts

2026-01-15

Expected to finish

2026-07-15

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of generalized gingivitis (Gingival Index > 1).
• Presence of at least 20 natural teeth.
• Systemically healthy individuals.
• Ability to provide informed consent.

You may not qualify if…

• Smoking or use of tobacco products.
• Presence of periodontitis (no clinical attachment loss).
• Use of antibiotics or anti-inflammatory drugs in the last 6 months.
• Pregnancy or lactation.
• History of allergy to Morus nigra or mouthwash components.
• Systemic diseases (Diabetes, cardiovascular diseases, etc.).

Where it is running

• Inonu University Faculty of Dentistry — Battalgazi, Malatya, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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