Fertility and Polycystic Ovary Syndrome
Starting soon
Conditions studied: Polycystic Ovary Syndrome (PCOS)
In brief
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age and affects approximately 10% of women worldwide. The diagnosis is based on the Rotterdam criteria established in 2003 and updated in the latest recommendations from the European Society of Human Reproduction (ESHRE) in 2023. The diagnosis of PCOS is based on the presence of 2 of the following 3 criteria: 1. Oligo-anovulation 2. Clinical and/or biological hyperandrogenism 3. Polycystic ovary morphology (PCOM) on imaging It is also the leading cause of anovulatory infertility, with a 15-fold increased risk of infertility. It is therefore a major cause of anovulatory infertility, but its pathophysiological mechanisms remain complex and multifactorial, involving interactions between genetic, metabolic, hormonal, and environmental factors. Prior to embarking on a fertility treatment plan, it is essential to better understand how these various factors influence ovarian function and reproductive capacity in patients with PCOS. Identifying and characterizing factors associated with fertility-such as hormonal profiles, insulin sensitivity, and metabolic markers-could help better predict future fertility and optimize personalized care and fertility outcomes. The aim of this study is therefore to identify modifiable factors influencing the fertility of PCOS patients phenotyped at La Pitié-Salpêtrière hospital.
Key facts
- Study ID
- NCT07499518
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 473
- Starts
- 2026-06-01
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-06-10
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may not qualify if…
- A prior diagnosis of type 1 or type 2 diabetes
- A diagnosis of non-classical adrenal block
- Use of hormonal therapy, oral antidiabetic medication, lipid-lowering medication, antihypertensive medication, corticosteroids, or spironolactone
- Menopause or current pregnancy
- Lack of data on BMI, insulin levels, and fasting blood glucose
- Patients who do not speak French
- Patients under legal guardianship, conservatorship, or curatorship
Where it is running
- Endocrinology department, Pitié Salpêtrière hospital — Paris, France
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.