FAP-targeted PET/NIR in Lung Malignant Tumors
Recruiting now
Conditions studied: Non-Small Cell Lung Cancer, PET/CT, Neoadjuvant Therapy
In brief
Single center, prospective, diagnostic study. Patients with stage II-IIIB resectable NSCLC diagnosed by pathology were included. After receiving standard neoadjuvant therapy (chemotherapy/immunotherapy/combination therapy), FAPI-PET/CT and fluorescence imaging were performed one week before surgery. During the surgery, a near-infrared fluorescence navigation system was used to locate the tumor lesion. After surgery, the tumor bed range was determined by pathological gold standards (HE staining+immunohistochemistry), and the predictive efficacy and localization accuracy of FAPI-PET/fluorescence were compared and analyzed.
Key facts
- Study ID
- NCT07498933
- Run by
- Peking University People's Hospital
- People needed
- 200
- Starts
- 2025-06-03
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-04-01
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18 and 70 years old;
- Have complete clinical and imaging data;
- Prior to neoadjuvant therapy, the biopsy pathology showed lung cancer;
- Able to retain sufficient tumor tissue for testing and research;
- Sign informed consent.
You may not qualify if…
- Previously combined with other malignant tumors or received other anti-tumor treatments;
- Failure to collect sufficient tumor tissue for testing and research;
- The duration of neoadjuvant therapy is less than 3 cycles;
- The dynamic scanning image quality of multimodal probe PET cannot meet the analysis standards or is missing;
- Lack of clinical and imaging data;
- There are situations where other researchers consider it inappropriate to participate in this study
Where it is running
- Peking University People's Hospital — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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