Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients
Recruiting now
Conditions studied: Pulmonary Hypertension Due to Lung Diseases
In brief
Chronic lung diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension. This serious complication involves increased pressure in the lung vessels, which strains the heart and worsens outcomes. Since the early symptoms are unclear, diagnosis often occurs too late, underscoring the need for simple, noninvasive methods of early detection. A key driver of the disease is vascular remodeling, which involves the narrowing and stiffening of blood vessels. This process involves changes in the extracellular matrix, particularly in the understudied basement membrane. Our project examines how specific components, especially non-classical collagens, change during disease progression. As vessels remodel, detectable fragments enter the bloodstream, potentially creating a molecular fingerprint of the disease. By analyzing lung tissue and blood samples, the investigators aim to identify non-invasive biomarkers for earlier diagnosis, better patient classification, and more personalized treatment.
Key facts
- Study ID
- NCT07498244
- Run by
- Medical University of Graz
- People needed
- 80
- Starts
- 2026-07-01
- Expected to finish
- 2030-06-30
- Last updated by the study team
- 2026-04-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients undergoing lung transplantation with COPD or PF, with or without associated PH and PAH.
- Outpatient cohort with COPD or PF, with or without associated PH or PAH.
You may not qualify if…
- Presence of other lung diseases
- Signs of infection, such as pneumonia, pulmonary tuberculosis, or pleural effusions.
Where it is running
- Medical University of Graz — Graz, Styria, Austria (enrolling)
Full record on ClinicalTrials.gov
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