Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting

Completed · Not applicable

Conditions studied: Syphilis, HIV Infections

In brief

The purpose of this study is to determine if a strategy utilizing the Chembio HIV/syphilis rapid point-of-care (POC) test for diagnosis of HIV and syphilis in pregnant women attending prenatal clinics in Guatemala will increase screening and detection rates thereby resulting in higher rates of treatment during pregnancy and ultimately reducing congenital syphilis and HIV Mother-to-child transmission (MTCT) and to provide knowledge and technical expertise on the use of Point-of-care ultrasound for all pregnant patients testing positive for syphilis during the intervention to evaluate the fetus for evidence of congenital syphilis.

Key facts

Study ID

NCT07498153

Run by

The University of Texas Health Science Center, Houston

People needed

149

Starts

2025-09-30

Expected to finish

2025-10-02

Last updated by the study team

2026-03-27

Who can join

Age: 14 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• pregnant women at any gestational age
• Nonpregnant women may also be included if unsure of pregnancy status and attend clinic for pregnancy care and confirmed to be not pregnant by routine testing such as urine pregnancy tests and/or the absence of an intrauterine pregnancy by ultrasound

You may not qualify if…

• Participants not at clinical sites in Puerto Barrios, Guatemala between 09/27/2025 and 10/03/2025

Where it is running

• The University of Texas Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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