Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy

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Conditions studied: Renal Cell Carcinoma (RCC), Renal Function Abnormal

In brief

It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.

Key facts

Study ID

NCT07497958

Run by

Sun Yat-sen University

People needed

174

Starts

2026-04-01

Expected to finish

2028-12-31

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery
• Aged 18 to 80
• Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center)
• Blood routine test: WBC≥3.5×10\^9/L, absolute neutrophil count ≥1.5×10\^9/L, PLT≥75.0×10\^9/L, HGB≥80g/L;
• Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN;

You may not qualify if…

• The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery
• Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes
• Estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m²
• Horseshoe kidney
• Solitary kidney
• Pregnant women

Where it is running

• 651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China

Full record on ClinicalTrials.gov

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