Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients
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Conditions studied: Post Dural Puncture Headache
In brief
Some patients develop headache after spinal anesthesia used during cesarean section. This condition is called post-dural puncture headache (PDPH). Early identification of patients at risk may improve patient care. This study evaluates whether optic nerve sheath diameter (ONSD), measured using a non-invasive bedside ocular ultrasound technique, can help predict the development of PDPH. Participants undergoing cesarean section with spinal anesthesia will undergo ONSD measurements at predefined perioperative time points. Participants will be followed postoperatively for the occurrence of headache. The findings may help improve early recognition and management of PDPH.
Key facts
- Study ID
- NCT07497945
- Run by
- Kocaeli University
- People needed
- 220
- Starts
- 2026-03-20
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-03-27
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women aged 18 to 45 years
- Singleton pregnancy
- Planned cesarean section (elective or emergency due to fetal indications)
- Spinal anesthesia planned for the procedure
- American Society of Anesthesiologists (ASA) physical status II-III
- Normal coagulation parameters (INR less than 1.5, platelet count greater than 100,000/mm³)
- Ability to provide written informed consent and cooperate with study procedures
You may not qualify if…
- Known ophthalmologic diseases affecting the optic nerve or retina (e.g., glaucoma, optic atrophy)
- Active eye infection or recent ocular surgery
- Known intracranial pathology affecting cerebrospinal fluid dynamics (e.g., intracranial mass, hydrocephalus, idiopathic intracranial hypertension)
- History of stroke or subarachnoid hemorrhage
- Hypertensive disorders of pregnancy such as preeclampsia or eclampsia
- Contraindications to spinal anesthesia (e.g., coagulopathy, anticoagulant therapy, infection at puncture site)
- Allergy to local anesthetics
- Conversion to general anesthesia due to failed or inadequate spinal block
- Presence of moderate or severe preoperative headache or active primary headache disorders such as migraine
Where it is running
- Kocaeli University Faculty of Medicine Hospital — Köseköy, Kocaeli, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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