Identification of Responders to Platelet-Rich Plasma (PRP) Injections in Lateral Elbow Epicondylalgia

Recruiting now

Conditions studied: Lateral Epicondylitis of the Elbow

In brief

The goal of this non-interventional study is to identify patients who respond to platelet-rich plasma (PRP) injections for chronic lateral epicondylalgia (tennis elbow) and to investigate factors associated with treatment response. The study will include approximately 139 adults (18 years and older) with chronic lateral elbow pain who received a PRP injection within the last 48 hours. The main question it aims to answer is: How many patients respond to PRP treatment for chronic lateral epicondylalgia at 90 days after injection? Secondary questions include: Which clinical, demographic, and occupational factors are associated with response to PRP? Can a predictive model be developed to identify patients likely to respond to PRP? How do pain, hand grip strength, and functional outcomes evolve over 90 days in responders versus non-responders? Participants will: Attend three visits at baseline (Day 0), Day 45, and Day 90. Undergo clinical examinations, pain assessments (EVA, DN4), functional tests (hand grip, PRTEE), and questionnaires. Have data on professional activities, medical history, and treatments collected. All procedures are part of routine care, except for the addition of the Clinical Global Impression - Change (CGI-C) scale at Day 45 and Day 90 to assess treatment response. The study will be conducted at the CMRRF de Kerpape and the CHU de Rennes in France. Each participant will be followed for approximately 3 months.

Key facts

Study ID

NCT07496983

Run by

Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape

People needed

139

Starts

2023-08-04

Expected to finish

2026-08-01

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Chronic lateral epicondylalgia (tennis elbow), diagnosed clinically or by imaging (ultrasound or MRI), evolving for more than 3 months
• PRP injection received within the last 48 hours
• Medically stable
• Able to provide informed consent/non-opposition
• Affiliation to a social security system

You may not qualify if…

• PRP injection received more than 48 hours before inclusion
• Participation in another clinical study with exclusion period
• Adults under legal protection
• Pregnant women

Where it is running

• Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles (CMRRF) de Kerpape — Ploemeur, France (enrolling)

Full record on ClinicalTrials.gov

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