A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Recruiting now · Phase 2/Phase 3
Conditions studied: Macular Degeneration, Age-Related Macular Degeneration, Choroidal Neovascularization, Wet Macular Degeneration
In brief
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Key facts
- Study ID
- NCT07496567
- Run by
- EyeBiotech Ltd.
- People needed
- 960
- Starts
- 2026-04-15
- Expected to finish
- 2028-07-31
- Last updated by the study team
- 2026-08-06
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- The Retina Partners — Encino, California, United States (enrolling)
- Northern California Retina Vitreous Associates Medical Group, Inc. — Mountain View, California, United States (enrolling)
- Orange County Retina Medical Group — Santa Ana, California, United States (enrolling)
- Retina Consultants of Southern Colorado — Colorado Springs, Colorado, United States (enrolling)
- RSC Research LLC — Denver, Colorado, United States (enrolling)
- Retina Consultants of Southern Colorado — Pueblo, Colorado, United States (enrolling)
- Connecticut Eye Consultants, P.C. — Danbury, Connecticut, United States (enrolling)
- Retina Consultants, P.C. — Manchester, Connecticut, United States (enrolling)
- Retina Group of New England — Waterford, Connecticut, United States (enrolling)
- Retina Group of Florida — Fort Myers, Florida, United States (enrolling)
- Florida Retina Institute — Orlando, Florida, United States (enrolling)
- Retina Group of Florida (Site 065) — Sarasota, Florida, United States (enrolling)
- Center for Retina and Macular Disease (Site 062) — Winter Haven, Florida, United States (enrolling)
- Illinois Retina Associates — Joliet, Illinois, United States (enrolling)
- University Retina & Macula Associates, P.C. — Lemont, Illinois, United States (enrolling)
- Wolfe Eye Clinic — West Des Moines, Iowa, United States (enrolling)
- Retina Associates, LLC — Lenexa, Kansas, United States (enrolling)
- Butchertown Clinical Trials — Louisville, Kentucky, United States (enrolling)
- Maine Eye Center (Site 097) — Portland, Maine, United States (enrolling)
- Mid Atlantic Retina Specialists — Hagerstown, Maryland, United States (enrolling)
- Retina Research Institute at New England Retina Consultants, PC — Springfield, Massachusetts, United States (enrolling)
- Retina Consultants of Minnesota — Edina, Minnesota, United States (enrolling)
- Envision Ocular, LLC — Bloomfield, New Jersey, United States (enrolling)
- Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY — Great Neck, New York, United States (enrolling)
- Associated Retina Consultants - Gilbert — Gilbert, Arizona, United States (enrolling)
Full record on ClinicalTrials.gov
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