Randomized Clinical Trial of Endovascular Recanalization for Symptomatic Non-Acute Intracranial Artery Occlusion（REPAIR）
Starting soon · Not applicable
Conditions studied: Symptomatic Non-acute Intracranial Artery Occlusion, Ischemic Stroke
In brief
A multicenter, randomized, open-label, endpoint-blinded trial to compare the effects of endovascular recanalization plus aggressive medical management with aggressive medical management alone on stroke recurrence and mortality in patients with symptomatic non-acute intracranial artery occlusion.
Key facts
- Study ID
- NCT07495969
- Run by
- Feng Gao
- People needed
- 286
- Starts
- 2026-04-01
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-03-27
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Severe stenosis (70%-99%) or occlusion of other arteries, or tandem stenosis (70%-99%) that is proximal to the qualifying artery.
- Intracranial hemorrhagic diseases such as definite Intracranial tumors, any intracranial vascular malformations, hemorrhagic transformation of infarction, spontaneous intracranial hemorrhage (cerebral parenchymal, subarachnoid, subdural, or epidural) within 30 days.
- Non atherosclerotic intracranial artery disease: arterial dissection, moyamoya disease or moyamoya syndrome demonstrated by imaging examination, or a definite medical history of autoimmune vasculitis.
- Evidence of cardioembolic embolism such as atrial fibrillation, prosthetic valve(s), infective endocarditis, mitral stenosis, atrial myxoma, intracardiac clot or vegetation, left ventricular aneurysms, etc.
- Known unstable angina or myocardial infarction within the last 6 months.
- Intolerance or allergic reaction to any treatment-related medication, including aspirin, clopidogrel, heparin, and local or general anesthetics.
- History of life-threatening allergy to contrast dye.
- Severe liver impairment (AST or ALT > 3 times normal, cirrhosis), serum creatinine > 3.0 mg/dl.
- Past history of EC-IC bypass surgery or EVT.
- Major surgery (including open femoral, aortic, or carotid surgery) within previous 30 days or planned in the next 90 days after enrollment.
- Late-stage malignant tumors, cachexia, or other serious diseases and an expected life expectancy of less than 1 year.
- Pregnant, perinatal stage or lactating women.
- Any other condition (in the opinion of the site investigator) that inappropriate to participate this study.
Where it is running
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing Municipality, China
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.