Tetris Intervention Following Subliminal Reactivation for Intrusive Memories
Starting soon · Not applicable
Conditions studied: Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
In brief
Post-Traumatic Stress Disorder (PTSD) is characterized by recurrent, intrusive memories of traumatic events that cause significant distress and functional impairment. Although trauma-focused treatments are effective, they typically require deliberate recollection of traumatic experiences, which can be distressing and may contribute to treatment avoidance or dropout. In previous experimental studies conducted with healthy participants, we demonstrated that unconscious reactivation of trauma-related cues, followed-after a brief delay corresponding to the memory reconsolidation window-by a visuospatial interference task (Tetris gameplay), reduced the frequency and emotional intensity of intrusive memories. These findings suggest that memory representations may be modifiable during reconsolidation without requiring conscious recall. Building on this work, the present randomized controlled trial (RCT) aims to evaluate the clinical efficacy and tolerability of this reconsolidation-based intervention in trauma-exposed individuals experiencing five or more intrusive memories per week.
Key facts
- Study ID
- NCT07495917
- Run by
- Shaanxi Normal University
- People needed
- 106
- Starts
- 2026-04-10
- Expected to finish
- 2027-07-30
- Last updated by the study team
- 2026-04-06
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Meet DSM-5 PTSD Criterion A (eg, exposure to actual or threatened death). Have experienced one or more traumatic events.
- Experienced five or more intrusive memories during the baseline week.
- Have internet access and have access to a personal computer.
- Be willing to provide consent and able to complete study procedures and be contacted by the study team.
You may not qualify if…
- Have fewer than five intrusive memories during the baseline week.
- A current diagnosis of schizophrenia, obsessive-compulsive disorder (OCD), a severe personality disorder judged to interfere with treatment adherence, or acute suicidal behavior.
- Have severe substance dependence.
Full record on ClinicalTrials.gov
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