Insights Into Pediatric Pulmonary Hypertension: A Real-World Registry of Epidemiology and Outcomes

Recruiting now

Conditions studied: Pulmonary Hypertension

In brief

Pediatric pulmonary hypertension (PH) shares similarities with PH in adulthood, but specific differences still require unique approaches. Despite major advances, risk scores for pediatric PH still need to be validated, and targeted drug therapies in pediatric populations remain under-studied. Consequently, there is a great need for comprehensive real-world longitudinal data of pediatric PH. The INSPIRE-PH registry is a multicenter, observational, real-world registry designed to systematically collect longitudinal clinical data on children and adolescents with PH. Patients enrolled in the registry receive standard clinical care determined by their treating physicians. No study-mandated interventions are imposed. Longitudinal observation of this cohort aims to provide important insights into disease progression, treatment effectiveness, and long-term prognosis in pediatric PH. The cohort was initially established prospectively in 2006, with all cases reclassified according to the 7th World Symposium for Pulmonary Hypertension (WSPH) criteria in 2024, and new patients continue to be prospectively enrolled. The registry is supervised by the principal investigator, independently from the financial sponsors.

Key facts

Study ID

NCT07495774

Run by

Guangdong Provincial People's Hospital

People needed

450

Starts

2006-01-04

Expected to finish

2035-12-31

Last updated by the study team

2026-03-27

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children and adolescents aged <18 years at diagnosis
• Diagnosed pulmonary hypertension (PH) according to the prevailing diagnostic criteria at the time of enrollment
• Enrollment in the registry at participating centers
• Provision of informed consent by patients and/or legal guardians
• Availability for longitudinal follow-up

You may not qualify if…

• Inability to confirm PH diagnosis due to insufficient clinical or hemodynamic data
• Refusal or inability to provide informed consent

Where it is running

• Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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