Pre-Post Multimodal Assessment Of Severe Psoriasis Vulgaris Using Clinical, Dermoscopic And QoL Measures

Starting soon

Conditions studied: Psoriasis Vulgaris

In brief

The goal of this observational study is to learn about the comprehensive changes in severe plaque psoriasis (Psoriasis Vulgaris) in adult participants undergoing standard treatment. The main questions it aims to answer are: How clinical signs of psoriasis, such as redness, scaling, and thickness, change after treatment? How specific skin features, visualized under dermoscopy, change after treatment? How participants' perceptions of psoriasis-related disability and overall quality of life improve after treatment? Participants will undergo standard medical treatment for severe psoriasis. Participants will be evaluated at the beginning of the study and again after treatment using clinical skin examinations, dermoscopic imaging, and validated questionnaires (Psoriasis Disability Index and quality of life parameters).

Key facts

Study ID

NCT07495657

Run by

Assiut University

People needed

45

Starts

2026-05-01

Expected to finish

2027-11-01

Last updated by the study team

2026-03-27

Who can join

Age: 6 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥ 6 years of age
• Newly diagnosed patients with plaque psoriasis with affected BSA >10%
• Indicated for a new systemic therapy (e.g., oral agent, biologics).
• Willing and able to provide informed consent for all procedures .
• At least one eligible, representative target plaque for serial dermoscopic imaging .
• Stop previous systemic therapy at least 2-3 months

You may not qualify if…

• • Non cooperative patients .
• Pregnant or breastfeeding women

Full record on ClinicalTrials.gov

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