Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.
Starting soon · Not applicable
Conditions studied: Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp
In brief
To compare the effect of 1% melatonin gel versus calcium hydroxide as intra canal medication in necrotic mandibular premolars on: * Intensity of postoperative pain. * Bacterial load reduction. * Periapical (MMP-9) level.
Key facts
- Study ID
- NCT07495605
- Run by
- Cairo University
- People needed
- 50
- Starts
- 2026-03-22
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-03-27
Who can join
Age: 21 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age between 18-50 years old.
- Males and females.
- Healthy patients categorized as I or II according to The American Society of Anesthesiologists. (ASA I or II), with no underlying allergies.
- Single-rooted mandibular premolar teeth, having single root canal: diagnosed clinically with pulp necrosis.
- Patients accepting to participate in the trial.
- Patients who can understand pain scale (Appendix I) and can sign the informed consent (Appendix II).
You may not qualify if…
- Medically compromised patients having significant systemic disorders (ASA III or IV).
- Pregnant females.
- If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.
- Teeth with multiple canals.
- Teeth that show association with acute periapical abscess or swelling.
- Teeth with vital pulp.
- Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam.
- Immature teeth.
- Teeth with greater than grade I mobility or pocket depth greater than 4 mm.
- Teeth showing radiographic evidence of external or internal root resorption, vertical root fracture, perforation or calcification.
- Patients with two or more adjacent teeth requiring endodontic treatment.
- Patients reporting bruxism, clenching or TMJ problems.
- Teeth with previous endodontic treatment.
- Inability to perceive the given instructions.
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