IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

Starting soon · Not applicable

Conditions studied: Knee Osteoarthritis, Knee Discomfort, Knee Pain Chronic, Knee Swelling Pain

In brief

Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patients do not benefit from GAE, and responses vary across individual patients. Changes in metabolic activity on non-invasive imaging may correlate with improvement in symptoms of knee osteoarthritis. This study will assess changes in metabolic uptake on a hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) system in subjects undergoing GAE.

Key facts

Study ID

NCT07494838

Run by

Lucas R. Cusumano, MD

People needed

25

Starts

2026-06-30

Expected to finish

2027-06-30

Last updated by the study team

2026-03-27

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provided informed consent
• Age ≥ 40 years
• Ineligibility for or refusal of surgical management
• Moderate-severe knee pain as determined by visual analog scale > 5 out of 10
• Osteoarthritis based on X-ray. Kellgren-Lawrence score > 2 based on radiograph completed within 3 months of procedure date
• Resistant/failed some form of conservative treatment (e.g. NSAIDS/physical therapy/steroid joint injection/hyaluronic acid joint injection) for at least 3 months
• Able to comply with all treatments and protocol follow-up visits

You may not qualify if…

• Mild knee pain as determined by visual analog scale < 5 out of 10
• OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation
• Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL/min.
• Significant arterial atherosclerosis that would limit selective angiography
• History of fibromyalgia, autoimmune, or inflammatory disorder
• History of any lumbar spine surgery, spine injections, or radicular pain in the extremity believed to originate from the spine
• Allergy to iodinated contrast agents
• Active infection or malignancy
• Recent (within 12 months) or active cigarette use
• Prior total or partial knee replacement in the subject knee
• Active pregnancy
• Uncorrectable bleeding diathesis
• Presence of pacemakers, aneurysm clips, neurostimulators, or any other metal implant not compatible with PET/MRI

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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