Risk Assessment of Pancreatic Islet Autoimmunity in Patients With AITD

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Conditions studied: Autoimmune Thyroid Disease

In brief

This study aims to evaluate the risk of islet autoimmunity in patients with autoimmune thyroid disease (AITD), describe related clinical and laboratory characteristics, and explore the development of a risk assessment model based on clinical, laboratory, and genetic markers. Adults aged 18-60 years with confirmed AITD will undergo baseline assessment including demographic data, anthropometric measures, lifestyle factors, medical history, thyroid-related clinical information, thyroid function, and thyroid antibody testing. A baseline blood sample will be collected for measurement of islet autoantibodies (GADA, IA-2A, ZnT8A, and IAA). Participants with positive islet autoantibodies will undergo further evaluation of glucose metabolism and beta-cell function, including HbA1c, OGTT, insulin, and C-peptide testing. Genome-wide genetic data will be used to construct a type 1 diabetes-related genetic risk score, and additional HLA genotyping may be performed in autoantibody-positive participants. The study will assess the prevalence and profile of islet autoantibodies in AITD and identify clinical, laboratory, and genetic factors associated with islet autoantibody positivity.

Key facts

Study ID

NCT07494474

Run by

Nanjing Medical University

People needed

834

Starts

2026-08-31

Expected to finish

2028-04-30

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

Full record on ClinicalTrials.gov

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