Exploring the Physiological Mechanisms of Austism Through Organoids

Starting soon

Conditions studied: Autism Spectrum Disorder (ASD

In brief

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting approximately 1% of the population, characterized by difficulties with social interaction and communication. Studies have identified more than 200 genes linked to ASD, particularly those involved in chromatin remodeling and synaptic neuronal connectivity (CHD8, SCN2A, NLGN3-4X, SHANK1-3). The goal of the project is to decipher the biological mechanisms underlying ASD in order to develop therapeutic strategies, using innovative preclinical models such as organoids.

Key facts

Study ID

NCT07494331

Run by

Assistance Publique - Hôpitaux de Paris

People needed

80

Starts

2026-05-01

Expected to finish

2028-05-01

Last updated by the study team

2026-03-27

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• A child diagnosed with an autism spectrum disorder in accordance with clinical practice guidelines
• A sibling without an autism spectrum disorder (SRS < 65)
• Biological parents
• Children and parents must be enrolled in a social security program, Universal Health Coverage (CMU), or an equivalent program.

You may not qualify if…

• Refusal to undergo a blood test
• Uncontrolled (unstabilized) medical condition (including psychiatric conditions) that precludes participation in the study
• Sibling with an SRS score > 65 at screening or under 2 years old

Where it is running

• Robert Debré Hospital — Paris, France

Full record on ClinicalTrials.gov

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