CAPTURE-HFpEF: National Study of Identification and Phenotyping of Heart Failure With Preserved Ejection Fraction

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Conditions studied: Heart Failure With Preserved Ejection Fraction (HFPEF)

In brief

The goal of this observational study is to improve early detection, characterization, and understanding of heart failure with preserved ejection fraction (HFpEF) in adults at risk of or diagnosed with HFpEF, including men and women across Danish regions. The main questions to answer are: Can systematic cardiovascular screening and deep phenotyping improve early identification and classification of HFpEF? Which clinical, imaging, biomarker, and metabolic characteristics define subtypes (phenotypes) of HFpEF and predict disease progression and outcomes? Researchers will compare participants with HFpEF, participants at risk of HFpEF, and relevant control groups to see if differences in biomarkers, imaging findings, and clinical characteristics can identify early disease stages and distinct HFpEF phenotypes. Participants identified with HFpEF will: * Undergo detailed cardiovascular examinations (e.g., echocardiography, CT and other imaging examinations, RHC, CPET) * Provide blood and tissue samples for biomarker and metabolic analyses * Complete clinical assessments and questionnaires * Have relevant health data collected from national health registries * Attend follow-up assessments to monitor disease progression

Key facts

Study ID

NCT07493590

Run by

Herlev and Gentofte Hospital

People needed

30000

Starts

2026-04-01

Expected to finish

2035-04-01

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients >60 years with ≥1 risk factor, OR
• Patients >50 years with ≥2 risk factors
• Hypertension
• Type 1 or 2 diabetes
• Chronic kidney disease (eGFR <60 mL/min/1.73 m²)
• Previous cardiotoxic drug exposure
• atrial fibrillation
• Ischemic heart disease
• Previous heart valve surgery/intervention
• Body mass index >30 kg/m² (self-reported)
• Use of ≥40 mg furosemide
• Obstructive sleep apnea
• Non-alcoholic fatty liver disease

You may not qualify if…

• Cancer <1 year
• Dialysis
• COPD and O2
• Nursing home
• Age >90 years
• Dementia
• Known dilated cardiomyopathy
• Prior organ-transplantation
• Amyloidosis

Where it is running

• Herlev and Gentofte Hospital — Copenhagen, Denmark

Full record on ClinicalTrials.gov

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