A Behavioral Application for Improving Smoking Cessation Among Smokers
Starting soon · Not applicable
Conditions studied: Cigarette Smoking-Related Carcinoma
In brief
This clinical trial compares two smartphone applications, called Actify! (A \& B) for improving smoking cessation outcomes in individuals who smoke. Actify! A is an app grounded in behavioral activation therapy, an evidence-based treatment for depression that can also be used to modify health behaviors such as smoking. The Actify! B app provides evidence-based tobacco cessation strategies based on current clinical guidelines.
Key facts
- Study ID
- NCT07493252
- Run by
- Fred Hutchinson Cancer Center
- People needed
- 1812
- Starts
- 2026-08-01
- Expected to finish
- 2029-07-31
- Last updated by the study team
- 2026-06-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18 or older
- Currently smoke, averaging at least 5 cigarettes/day for the last 30 days
- Interested in quitting smoking in the next 30 days
- Experience downloading and using one or more apps on their smartphone
- Either screens negative for depression (Patient Health Questionnaire - 9 item [PHQ-9] score 0-4; n = 906) or screens positive for mild to moderately severe current depressive symptoms (PHQ-9 score 5-19; n = 906)
- Willing and able to complete all study activities and to receive compensation by mail
- Comfortable reading and writing in English
- Have a mobile data plan and/or access to WiFi to support the use of the assigned app
- Reside in the United States (US)
- Willing to provide information for an emergency contact in case of serious concerns about the participant's physical or mental health
You may not qualify if…
- Self-report of currently receiving behavioral treatment for depression (e.g., psychotherapy or counseling, web- or app-based interventions); current use of pharmacotherapy for depression or for other mental health conditions that are not otherwise excluded is allowable (e.g., benzodiazepines, anticonvulsants, opioid agonists, antipsychotics)
- Severe depression (PHQ-9 ≥ 20)
- Current suicidal ideation reported on the PHQ-9
- History of a suicide attempt
- Self-reported lifetime diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, antisocial personality disorder, or borderline personality disorder; or self-reported lifetime diagnosis of an alcohol or drug use disorder with use of the substance(s) in the past 30 days
- Currently receiving other smoking cessation treatments, including pharmacotherapies (nicotine replacement therapy, bupropion, or varenicline) and behavioral interventions (e.g. quitline counseling, other digital health programs), but excluding electronic (e)-cigarettes/vaping
- Previous use of the QuitGuide program
- Employees/family of investigator or study center
- Member of the same household as another participant
- Woman who is pregnant or breastfeeding, or planning to become pregnant
- Having a Google voice number as their primary phone number (due to association with fraudulent study entry attempts in our previous work)
- Currently incarcerated
- Participated in earlier studies to develop the Actify! app
Where it is running
- Fred Hutch/University of Washington Cancer Consortium — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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