USG-Guided Shoulder Injections in Frozen Shoulder

Recruiting now · Not applicable

Conditions studied: Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, Nociplastic Pain, Neuropathic Pain

In brief

Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life. This study aims to evaluate the effectiveness of USG-guided shoulder injections, when added to a home-based exercise program, in the conservative management of patients with chronic, painful frozen shoulder. In this prospective randomized study, patients diagnosed with painful frozen shoulder will be included. In addition to a standardized home-based exercise program, patients will receive either USG-guided suprascapular nerve block alone or a combination of suprascapular nerve block and subacromial injection. The effects of these approaches on clinical outcomes will be assessed over a 20-week follow-up period. Primary outcome measures include pain intensity assessed by the Visual Analog Scale (VAS), functional status evaluated by the Shoulder Pain and Disability Index (SPADI), and shoulder range of motion. Secondary outcomes include depression level (Beck Depression Inventory), sleep quality, pain phenotype (nociplastic, neuropathic, or nociceptive), hand grip strength, ultrasonographic findings ( (coracohumeral ligament thickness, subacromial bursa thickness) , and patient satisfaction (subjective impression of improvement). The results of this study are expected to provide evidence on the comparative effectiveness and additional benefits of different shoulder injection approaches when combined with home-based exercise therapy in patients with chronic frozen shoulder.

Key facts

Study ID: NCT07493213
Run by: Konya Beyhekim Training and Research Hospital
People needed: 68
Starts: 2026-04-01
Expected to finish: 2027-06-30
Last updated by the study team: 2026-05-14

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age between 18 and 75 years and willingness to participate in the study
Presence of shoulder pain lasting at least 3 months and a diagnosis of primary frozen shoulder
Pain intensity ≥ 4/10 on the Visual Analog Scale (VAS), resistant to medical treatment/analgesics
Restriction of ≥30 degrees in at least two planes of shoulder motion (flexion, abduction, or external rotation)

You may not qualify if…

History of shoulder trauma
Presence of neurological conditions such as stroke, brachial plexus injury, Parkinson's disease, or cervical spine pathology with or without radiculopathy
History of shoulder surgery, shoulder malignancy or tumor, or prior shoulder manipulation
Presence of shoulder arthritis, rotator cuff tear, other shoulder injuries, or thoracic outlet syndrome
Systemic diseases affecting the shoulder, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, labral or articular cartilage injuries), or inflammatory rheumatic diseases
Steroid injection to the affected extremity within the last 3 months, use of oral steroids or NSAIDs, or ongoing surgical/interventional treatment
Pregnancy or lactation
Uncontrolled diabetes, heart failure, or uncontrolled systemic diseases (e.g., liver failure, chronic kidney disease, significant endocrine disorders)
Communication problems or severe psychiatric disorders

Where it is running

Konya Beyhekim Training and Research Hospital — Konya, Selçuklu, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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