Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy

Recruiting now · Not applicable

Conditions studied: Cardiac Resynchronisation Therapy (CRT), Heart Failure, Conduction System Pacing

In brief

The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.

Key facts

Study ID

NCT07492979

Run by

Rigshospitalet, Denmark

People needed

1100

Starts

2026-06-17

Expected to finish

2031-07-01

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥18 years of age,
• LVEF ≤ 35%,
• NYHA Class II-IV (IV only outpatients),
• optimized in medical treatment (OMT)
• AND one of the following:
• . LBBB according to AHA/ACC/HRS Scientific Statement from 2009 and ≥130ms or
• LBBB-like intraventricular conduction delay (IVCD) > 150ms or RV paced QRS and indication for upgrade to CRT (> 40% RV pacing) OR
• ≥18 years of age,
• LVEF ≤ 40 %
• pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing.

You may not qualify if…

• recent acute myocardial infarction (AMI)
• coronary artery bypass graft (CABG) (<3 months)
• life expectancy <2 years, patients in hemodialysis
• treatment with a cardiac implantable electronic device (CIED) is contraindicated.
• Patients are excluded with regards to the MRI sub study if eGFR > 35 ml/min, in case or contrast allergy or certain metal implants.

Where it is running

• Rigshospitalet, Copenhagen University Hospital — Copenhagen, Denmark (enrolling)
• Dept. of Cardiology, Aarhus University Hospital, Aarhus — Aarhus, Denmark
• Dept of Cardiology, Meilahti Hospital, Helsinki — Helsinki, Finland
• Haukeland Universitetssykehus — Bergen, Norway
• Sahlgrenska University Hospital — Gothenburg, Sweden

Full record on ClinicalTrials.gov

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