MP101 in Adults With Acute Pseudomonas Aeruginosa Pneumonia

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Pneumonia - Bacterial, Pseudomonas Aeruginosa Infection

In brief

The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of MP101 administered in addition to standard antibiotic therapy in adult patients with acute Pseudomonas aeruginosa pneumonia. The study will also assess the pharmacokinetic and pharmacodynamic characteristics of MP101 and its antibacterial activity, including changes in P. aeruginosa burden in sputum and changes in susceptibility to MP101 and concomitant antibiotics.

Key facts

Study ID

NCT07492771

Run by

MicrobiotiX Co., Ltd

People needed

18

Starts

2026-07-25

Expected to finish

2026-12-01

Last updated by the study team

2026-07-28

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects aged 19 years or older.
• Clinical diagnosis of acute pneumonia with radiologic evidence of pulmonary infiltrates.
• Confirmed Pseudomonas aeruginosa (PA) infection via valid respiratory specimens.
• PA isolate demonstrates susceptibility to MP101 and non-susceptibility to current antibiotic therapy.
• Adequate organ function as defined by hematological, hepatic, and renal laboratory parameters .

You may not qualify if…

• Persistent septic shock or hemodynamically unstable condition.
• Active pulmonary tuberculosis or non-bacterial pneumonia.
• Significant pleural effusion or lung abscess requiring therapeutic drainage.
• Clinically significant cardiovascular, hepatic, or renal impairment .
• Immunocompromised status or hematological malignancies.
• Known hypersensitivity to bacteriophages, study components, or concomitant antibiotics.
• Participation in another clinical trial within 30 days prior to screening.
• Any medical condition that, in the opinion of the investigator, would make the subject unsuitable for the study.

Where it is running

• Severance Hospital — Seoul, Seodaemun-gu, South Korea (enrolling)

Full record on ClinicalTrials.gov

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