Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D

Recruiting now

Conditions studied: HEPATITIS B CHRONIC, Hepatitis D, Periodontitis

In brief

Periodontal disease is a chronic inflammatory condition associated with systemic diseases, highlighting the concept of periodontal medicine. This study aims to investigate the relationship between periodontal inflammation, oral lesions, and hepatitis B+D infection, with or without bulevirtide treatment. Oral-periodontal clinical parameters and targeted inflammatory biomarkers in saliva and gingival crevicular fluid will be evaluated in three groups: patients with hepatitis B+D receiving bulevirtide, patients with hepatitis B+D not receiving bulevirtide, and healthy controls.

Key facts

Study ID

NCT07491848

Run by

Research Center of Periodontal-Systemic Interactions

People needed

25

Starts

2026-02-15

Expected to finish

2027-02-15

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults (≥18 years old) capable of providing informed consent.
• For Hepatitis B+D groups: confirmed hepatitis B and D co-infection.
• Bulevirtide group: receiving bulevirtide therapy as prescribed.
• No Bulevirtide group: not receiving bulevirtide.
• For Healthy Control group: systemically healthy adults without hepatitis B or D infection.
• Willingness to undergo oral-periodontal examination, saliva and gingival crevicular fluid collection, and oral cavity photography.

You may not qualify if…

• Patients with other systemic diseases that could influence periodontal health (e.g., uncontrolled diabetes, autoimmune diseases).
• Patients currently receiving other experimental therapies that may affect oral or systemic inflammation.
• Pregnancy or lactation.
• Inability or unwillingness to provide informed consent.
• History of oral or periodontal surgery within the last 6 months that could affect measurements.

Where it is running

• Clinical Emergency County Hospital Craiova — Craiova, Romania (enrolling)
• University of Medicine and Pharmacy of Craiova — Craiova, Romania (enrolling)

Full record on ClinicalTrials.gov

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