Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Thumb Osteoarthritis

In brief

The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections improve pain and function in adults with thumb base osteoarthritis (CMC-I OA). The main questions it aims to answer are: Does a PRP injection reduce pain compared to a placebo (saline) injection? Does PRP improve hand function, strength, and thumb mobility? What adverse events occur following PRP treatment? Researchers will compare PRP injections to a placebo injection (saline solution) to determine whether PRP is an effective treatment for CMC-I osteoarthritis. Participants will: Receive a single ultrasound-guided injection of PRP or placebo (saline) in the CMC-I joint. Attend follow-up visits at 3, 6, 9, and 12 months for clinical assessments. Complete questionnaires on pain (VAS) and hand function (MHQ-DLV) at multiple time points. Undergo physical examinations (grip strength, pinch strength, thumb motion). Undergo ultrasound evaluations to assess joint characteristics.

Key facts

Study ID

NCT07491302

Run by

Goed Medisch Centrum

People needed

88

Starts

2026-04-01

Expected to finish

2027-06-01

Last updated by the study team

2026-04-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• Patients with an Eaton-littler score of I, II or III
• Patients with uni- or bilateral CMC-I osteoarthritis
• Non-responders to conservative therapy i.e., hand therapy and immobilisation after 3 months

You may not qualify if…

• Aged below 18
• Patients with an Eaton-littler score of IV (STT arthrosis)
• Surgical interventions of the CMC-I joint
• A known articular systemic disease (e.g. rheumatoid arthritis) or additional hand osteoarthritis/ tenosynovitis or metabolic disease like diabetes mellitus
• Patients with an infectious arthritis of CMC-I joint
• A known psychiatric condition
• Neuropathic chronic pain syndrome
• Intra articular injection 6 months prior to inclusion
• Smoking
• Active use of statins

Full record on ClinicalTrials.gov

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