QLS1410 in Participants With Uncontrolled Hypertension
Enrolling by invitation · Phase 2 · Has a placebo group
Conditions studied: Hypertension (HTN)
In brief
The goal of this clinical trial is to measure the efficacy and safety of QLS1410 in participants with uncontrolled hypertension (uHTN) or treatment-resistant hypertension (rHTN). The main objective is to compare the difference in systolic blood pressure（SBP) change from baseline at Week 12 of treatment between participants receiving QLS1410 tablets and participants receiving placebo tablets.
Key facts
- Study ID
- NCT07489612
- Run by
- Qilu Pharmaceutical Co., Ltd.
- People needed
- 260
- Starts
- 2026-04-01
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female participants must be ≥ 18 years old.
- Mean seated SBP ≥ 140 mmHg at Screening and at Baseline..
- Fulfil at least 1 of the following 2 criteria:
- Uncontrolled Hypertension (uHTN) subpopulation: have a stable regimen (≥ 4 weeks) of 2 antihypertensive medications, from different therapeutic classes (at least one must be a diuretic), at maximum tolerated dose in the judgement of the Investigator.
- Resistant Hypertension (rHTN) subpopulation: have a stable regimen (≥ 4 weeks) of ≥ 3 antihypertensive medications, from different therapeutic classes (at least one must be a diuretic), at maximum tolerated dose in the judgement of the Investigator.
You may not qualify if…
- Mean seated systolic blood pressure (SBP)≥ 180 mmHg.
- Mean seated diastolic blood pressure (DBP)≥ 110 mmHg.
- Estimated glomerular filtration rate < 45 mL/min/1.73m2.
- Serum potassium (K+) level <3.5 and ≥ 5.0 mmol/L.
- Has the following known secondary causes of hypertension: renal artery stenosis, uncontrolled or untreated hyperthyroidism, uncontrolled or untreated hypothyroidism, pheochromocytoma, Cushing's syndrome, aortic coarctation.
- NYHA functional heart failure class IV at Screening.
Where it is running
- Qilu Hospital of Shandong University — Jinan, China
Full record on ClinicalTrials.gov
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