A Clinical Study of QL1207H Injection Versus Aflibercept for Neovascular Age-related Macular Degeneration
Starting soon · Phase 3
Conditions studied: Neovascular Age-Related Macular Degeneration (nAMD)
In brief
The goal of this clinical trial is to evaluate the efficacy and safety of QL1207H injection versus aflibercept 8 mg in patients with neovascular age-related macular degeneration. The main question it aims to answer is: • Whether the efficacy and safety of QL1207H and aflibercept 8 mg are similar. Participants will receive injection once every 4 weeks for 3 consecutive doses, followed by injection once every 16 weeks at maximum. Researchers will compare QL1207H group and aflibercept 8 mg group to see if they are similar in improving best corrected visual acuity.
Key facts
- Study ID
- NCT07489586
- Run by
- Qilu Pharmaceutical Co., Ltd.
- People needed
- 356
- Starts
- 2026-03-01
- Expected to finish
- 2027-08-01
- Last updated by the study team
- 2026-03-24
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- At least 50 years of age.
- Active subfoveal CNV secondary to nAMD, including juxtafoveal lesions that affect the fovea as assessed in the study eye.
- Total area of CNV (including both classic and occult components) must comprise greater than 50% of the total lesion area in the study eye.
- Presence of IRF and/or SRF affecting the central subfield of the study eye on OCT.
- BCVA ETDRS letter score of 78 to 24 in the study eye.
You may not qualify if…
- Causes of CNV other than nAMD in the study eye.
- Total lesion size >12 disc areas; or subretinal hemorrhage that is at least 50% of the total lesion area, or if the blood under the fovea is 1 or more disc areas in size in the study eye.
- Scar, fibrosis, or atrophy involving the central subfield in the study eye.
- Uncontrolled glaucoma (defined as IOP >25 mmHg despite treatment with antiglaucoma medication) in the study eye.
- Myopia of a spherical equivalent of at least 8 diopters in the study eye prior to any refractive or cataract surgery.
Full record on ClinicalTrials.gov
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