Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis

Recruiting now · Phase 4

Conditions studied: Osteo Arthritis Knee, Osteoarthritis, Intraarticular Injection

In brief

This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis.

Key facts

Study ID

NCT07489521

Run by

Cappagh National Orthopaedic Hospital

People needed

200

Starts

2026-01-29

Expected to finish

2027-09-01

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults
• Symptomatic single side knee pain.
• Patients with diagnosis of knee osteoarthritis radiographic Kellgren and Lawrence system OA grade II-III-IV on x ray or MRI.

You may not qualify if…

• Inflammatory conditions,
• Cancer,
• acute infection,
• pregnancy and breastfeeding.
• Uncontrolled diabetes mellitus,
• Joint diseases in the knee, such as rheumatoid arthritis or gout, history of knee surgery with metallic implant.
• If patient has undergone knee arthroscopy in past 6 months.
• Intra-articular injection of corticosteroids during the previous 3 months, intra-articular injection of other drugs, such as hyaluronic acid over the previous 1 year.
• Contraindications for intra-articular injection, such as thrombocytopenia, coagulopathy, articular infection of knee, impairment of immunity.

Where it is running

• Cappagh National Orthopaedic Hospital — Dublin, Dublin, Ireland (enrolling)

Full record on ClinicalTrials.gov

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