Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reproductive Failure(RRF)
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Chronic Endometritis
In brief
A Prospective Randomized Controlled Trial, the goal of this clinical trial is to evaluate the efficacy and safety of doxycycline alone versus doxycycline plus medroxyprogesterone acetate (MPA) in women with chronic endometritis (CE), and to assess subsequent reproductive outcomes. Participants will be randomly assigned to one of two groups and will receive the assigned treatment. Participants will be followed for reproductive outcomes, including pregnancy , ongoing pregnancy, spontaneous miscarriage, and live birth.
Key facts
- Study ID
- NCT07488949
- Run by
- Fang Wang
- People needed
- 1000
- Starts
- 2024-04-09
- Expected to finish
- 2031-12-31
- Last updated by the study team
- 2026-03-23
Who can join
Age: 20 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- women aged 20-45 years;
- plans to conceive within 12 months;
- chronic endometritis(CE) confirmed by endometrial CD138 immunohistochemistry (IHC);
- a diagnosis of recurrent reproductive failure(RRF);
- willingness to undergo hysteroscopy and endometrial biopsy;
- no contraindications to the study medications.
You may not qualify if…
- acute genital tract infection, gynecologic malignancy, endometrial hyperplasia, or uterine fibroids;
- pregnancy or lactation;
- contraindications to hysteroscopy or anesthesia;
- use of antibiotics, glucocorticoids, estrogens, or progestins within 3 months before trial initiation;
- allergy to doxycycline or medroxyprogesterone acetate(MPA);
- abnormal semen parameters in the male partner.
Where it is running
- Lanzhou University Second Hospital — Lanzhou, Gansu, China (enrolling)
Full record on ClinicalTrials.gov
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