Intravenous Lidocaine Infusion in Lumbar Fusion Surgery

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Lumbar Fusion Surgery

In brief

Elective lumbar fusion surgery is associated with moderate to severe postoperative pain and often requires substantial perioperative opioid administration. Excessive opioid use may lead to adverse effects such as nausea, vomiting, sedation, respiratory depression, and delayed mobilization. Intravenous lidocaine infusion has been proposed as part of multimodal analgesia because of its analgesic, antihyperalgesic, and anti-inflammatory properties. This randomized, placebo-controlled clinical trial aims to evaluate the effect of intraoperative intravenous lidocaine infusion on postoperative opioid consumption and early recovery outcomes in patients undergoing elective lumbar fusion surgery. Patients will be randomly assigned to receive either intravenous lidocaine infusion or placebo during surgery. The primary outcome is cumulative postoperative opioid consumption within the first 24 hours after surgery. Secondary outcomes include intraoperative opioid consumption, postoperative pain scores, time to first rescue analgesic, quality of recovery, postoperative nausea and vomiting, time to mobilization, and length of hospital stay. In addition, inflammatory and oxidative stress biomarkers including interleukin-6 (IL-6) and markers of thiol-disulfide homeostasis will be measured preoperatively and postoperatively.

Key facts

Study ID

NCT07488832

Run by

Ankara City Hospital Bilkent

People needed

110

Starts

2026-04-01

Expected to finish

2027-01-01

Last updated by the study team

2026-04-08

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18 and 65 years
• Scheduled for elective lumbar fusion surgery under general anesthesia
• American Society of Anesthesiologists (ASA) physical status I-II
• Ability to provide written informed consent

You may not qualify if…

• Refusal to participate in the study
• ASA physical status ≥III
• Body mass index >35 kg/m²
• Known allergy or hypersensitivity to lidocaine or study medications
• Severe cardiac, hepatic, or renal disease
• Pregnancy
• Neurological disorders affecting pain assessment
• Chronic opioid use
• Use of opioids or antiemetic drugs before surgery
• Inability to cooperate with postoperative assessments

Where it is running

• Ankara Bilkent City Hospital — Ankara, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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