Radiographic Evaluation of Tumor Biology During Neoadjuvant Radiotherapy for Sarcoma

Starting soon · Not applicable

Conditions studied: Sarcoma

In brief

This is a single arm study in which patients will undergo MRI studies at 3 non-SOC timepoints (end of weeks 1, 3, and 5) while receiving SOC RT for their soft tissue sarcoma.

Key facts

Study ID

NCT07487870

Run by

Andrew Frankart

People needed

5

Starts

2026-05-01

Expected to finish

2027-12-01

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have histologically or cytologically confirmed history of soft tissue sarcoma.
• Plan to receive neoadjuvant radiation to a dose of 50 Gy in 25 fractions followed by surgical resection per Investigator.
• Age ≥18 years.
• ECOG performance status ≤2.

You may not qualify if…

• Patients with Ewing's sarcoma and rhabdomyosarcoma.
• Unable or unwilling to receive gadolinium-based contrast.
• Patients who are unable or unwilling to undergo MRI studies.
• Patients who may be unlikely or unable to be able to complete 3 additional MRI studies during the course of their 5-week radiation plan in the opinion of the PI.

Where it is running

• University of Cincinnati Medical Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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