Effect of Acupuncture on the Success Rate in Patients With Recurrent Implantation Failure

Starting soon · Not applicable · Has a placebo group

Conditions studied: Implantation Failure

In brief

To conduct a multi-center, randomized, controlled clinical study aimed at formally evaluating the impact of pressing therapy on the success rate in patients with recurrent implantation failure.

Key facts

Study ID

NCT07486297

Run by

Huazhong University of Science and Technology

People needed

208

Starts

2026-06-30

Expected to finish

2028-06-30

Last updated by the study team

2026-06-25

Who can join

Age: 20 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Meets the criteria for RIF diagnosis (≥ 2 instances of unsuccessful transfer of high-quality embryos).
• Age: 20 to 40 years old.
• Planning for a cycle involving the transfer of frozen-thawed embryos (FET).
• Possession of a transplantable D3 frozen embryo (≥6 cells) or a frozen blastocyst (≥3BC).
• Estradiol-progesterone replacement therapy: endometrial thickness ≥ 7 mm within the period of endometrial transformation.

You may not qualify if…

• Individuals planning to undergo preimplantation genetic diagnosis (PGD).
• Recipients of egg donations.
• Chromosomal abnormalities in either spouse or one partner (excluding chromosomal polymorphisms).
• Patients with known embryo-related factors leading to implantation failure.
• Abnormalities of the uterus that may affect implantation (including uterine malformations, uterine tuberculosis, submucosal myomas, severe uterine adhesions, severe uterine endometriosis, myomas with a diameter of ≥4 cm, and so on).
• Recurrent spontaneous abortions (loss of a fetus before 28 weeks of gestation occurring twice or more).
• Individuals with other endocrine disorders, such as thyroid disorders, hyperprolactinemia, insulin resistance, diabetes, and adrenal disorders, whose hormone levels have not been well-controlled over the past 3 months.
• Individuals with untreated hydrosalpinx;
• Individuals with a Body Mass Index (BMI) below 18 and above 25 kg/m2.
• Men with severe abnormalities in semen quality. Individuals with a history of needle phobia.

Where it is running

• Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China

Full record on ClinicalTrials.gov

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