Ultrasound Elastography of Carpal Tunnel Syndrome

Enrolling by invitation

Conditions studied: Carpal Tunnel Syndrome (CTS)

In brief

Carpal Tunnel Syndrome (CTS) is the most common peripheral nerve compression disorder in adults. Although electromyography (EMG) is the current gold standard for diagnosis, it is invasive, time-consuming, and may yield false-negative results. Ultrasound elastography, including shear wave elastography and strain elastography, enables non-invasive assessment of median nerve stiffness, reflecting fibrosis and edema. However, data on the combined use of elastography and microvascular imaging in CTS are still limited in Vietnam. This study aims to evaluate the value of advanced ultrasound techniques in diagnosing CTS and grading disease severity, as well as their correlation with clinical symptoms and EMG findings

Key facts

Study ID

NCT07486284

Run by

Da Nang Family General Hospital

People needed

80

Starts

2025-04-15

Expected to finish

2026-04-15

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Inclusion Criteria (Case Group)
• Patients >18 years old.
• Clinical suspicion of CTS with at least one sign: numbness/pain in the median nerve distribution (digits 1, 2, 3, and lateral 4), nocturnal symptoms, or positive provocative tests (Tinel, Phalen, Durkan).
• Confirmed diagnosis of CTS via Electrodiagnostic studies (NCS/EMG) based on American Academy of Neurology (AAN) and AANEM criteria.
• Inclusion Criteria (Control Group)
• Healthy volunteers with no clinical symptoms of CTS.
• Normal electrodiagnostic results.

You may not qualify if…

• Exclusion Criteria
• History of prior CTS treatment (steroid injection, surgery).
• Presence of cervical radiculopathy, polyneuropathy, or proximal median nerve entrapment.
• Secondary causes of CTS identified on ultrasound (e.g., gouty tophi, ganglion cysts, tumors, tenosynovitis).
• Anatomical variants such as a bifid median nerve or persistent median artery.
• Refusal to participate in the study

Where it is running

• Da Nang family general Hospital — Da Nang, Vietnam

Full record on ClinicalTrials.gov

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