Magnetic Resonance Imaging of the Lung: Oncological Applications

Recruiting now

Conditions studied: Lung Cancer (NSCLC)

In brief

Lung neoplasms are characterized by a complex interaction between tumor cells and a variety of resident and infiltrating host elements, secreted factors, and extracellular matrix proteins, collectively referred to as the microenvironment. Nowadays, in the setting of lung cancer, and in particular non-small cell lung cancer (NSCLC), the evaluation of microenvironment characteristics can only be performed by a pathologist and only on histological material. By combining different MRI parameters, it may be possible to create a specific imaging "signature" for the three different immune phenotypes and thus be able to make a distinction based on MRI examination.

Key facts

Study ID

NCT07486219

Run by

Fondazione IRCCS Policlinico San Matteo di Pavia

People needed

50

Starts

2020-01-15

Expected to finish

2026-04-01

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary NSCLC of the lung (TNM 8th edition T parameter ≥T1c)
• Biopsy examination of the primary tumor adequate at least for PDL-1 quantification
• Staging CT scan with uncertain N parameter and definite M parameter.

You may not qualify if…

• Absolute contraindications to magnetic resonance imaging or the administration of gadolinium-based contrast agents

Where it is running

• Fondazione IRCCS Policlinico San Matteo — Pavia, Italy (enrolling)

Full record on ClinicalTrials.gov

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