Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)
Starting soon
Conditions studied: Orthostatic Hypotension, Postprandial Hypotension
In brief
The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments. Orthostatic hypotension is defined as an excessive drop in blood pressure after standing up from a lying or sitting position. Postprandial hypotension is an excessive drop in blood pressure that occurs after eating a meal. These conditions can increase the risk of falls, fainting, loss of independence, and other health problems in older adults. The main questions this study aims to answer are: * How common orthostatic hypotension and postprandial hypotension are in hospitalized adults aged 65 years and older. * Whether these conditions are associated with medication use, chronic diseases, and geriatric syndromes (such as frailty, cognitive impairment, and functional decline). Participants will: * have blood pressure measured while lying down and standing * have blood pressure measured after a meal * undergo a comprehensive geriatric assessment, including evaluation of functional status, cognitive function, frailty, mobility, and nutritional status * provide information about medications and medical history * be followed for up to 12 months to record outcomes such as falls, syncope, hospitalization, and death
Key facts
- Study ID
- NCT07485998
- Run by
- University Medical Centre Ljubljana
- People needed
- 500
- Starts
- 2026-04-01
- Expected to finish
- 2030-06-01
- Last updated by the study team
- 2026-03-20
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 65 years or older
- Hospitalization in internal medicine departments at the University Medical Centre Ljubljana
- Duration of hospitalization ≥48 hours
- Hemodynamic stability confirmed by the treating physician
- Ability to participate in study procedures
- Ability to stand (with or without assistive devices for walking)
- Written informed consent obtained
You may not qualify if…
- Medical condition preventing study procedures (e.g., need for continuous supine position)
- Inability to provide informed consent
- Refusal to participate
- Severe cognitive impairment or delirium
- Acute critical illness requiring intensive treatment
- Participation in another clinical study that could affect safety or study outcomes
Where it is running
- University Medical Centre Ljubljana — Ljubljana, Slovenia
Full record on ClinicalTrials.gov
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