Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Recruiting now · Phase 4

Conditions studied: Total Knee Arthroplasty

In brief

The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.

Key facts

Study ID

NCT07485803

Run by

AdventHealth

People needed

192

Starts

2026-06-01

Expected to finish

2028-06-01

Last updated by the study team

2026-06-22

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of signed and dated informed consent from
• Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study.
• Age 21- 75
• Unilateral total knee arthroplasty at Colorado Joint Replacement
• All individuals will be screened for drug use (opioid use, illicit drug use) at their preoperative appointment
• For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.

You may not qualify if…

• Narcotic use in the past 6 weeks
• Current or previous history of drug and alcohol abuse
• Tobacco use in the previous 90 days
• Treatment with another investigational drug
• Patients that cannot receive spinal anesthesia
• Patients that cannot receive the standardized multimodal pain medications (i.e. Tylenol, gabapentin and meloxicam)'
• Patients that are not able to go home after leaving the hospital and require a short-term rehabilitation facility
• Obstructive sleep apnea
• Morbid obesity (BMI >40)
• Patients with liver disease.
• Significant kidney disease - stage 3 CKD or greater
• Pregnant or nursing females
• Baseline QTc >480
• severe COPD (GOLD 3 or 4)
• home oxygen requirement

Where it is running

• AdventHealth Porter — Denver, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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