Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma

Starting soon · Not applicable

Conditions studied: Melasma (Facial Melasma), Melasma

In brief

It's a prospective, randomised, assessor-blinded clinical study comparing topical 30% metformin with Kligman's regimen for melasma in women aged 35-55 years at Fauji Foundation Hospital, Rawalpindi. The study seeks to ascertain which treatment yields a more significant decrease in the modified MASI score over an 8-week period and which treatment is associated with fewer adverse effects, such as erythema, burning, peeling, and post-inflammatory hyperpigmentation. A total of 82 participants will be enrolled and randomly assigned to either metformin cream or Kligman's regimen, with both groups also using sunscreen. Assessments will be done at baseline, week 4, and week 8 through mMASI scoring, photographs, and side-effect monitoring. Data will be analyzed in SPSS 26 using t-tests and chi-square testing. The study is based on evidence suggesting metformin may offer comparable efficacy with better tolerability.

Key facts

Study ID

NCT07485777

Run by

Foundation University Islamabad

People needed

82

Starts

2026-07-01

Expected to finish

2027-06-01

Last updated by the study team

2026-03-20

Who can join

Age: 35 and older, up to 55. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients aged 35-55 years
• Clinically diagnosed epidermal or dermal melasma (confirmed by Wood's lamp examination)
• Fitzpatrick skin types III-V
• Duration of melasma ≥6 months
• No topical or systemic treatment for melasma in the past month

You may not qualify if…

• Pregnancy or lactation
• Known allergy to study medications
• Active facial dermatitis, acne, or recent cosmetic procedures

Where it is running

• Fauji Foundation Hospital, Rawalpindi — Rawalpindi, Punjab Province, Pakistan

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.