Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD

Recruiting now · Not applicable

Conditions studied: Obessive-Compulsive Disorder

In brief

Obessive-Compulsive Disorder (OCD) is frequently treatment-refractory and imposes a substantial burden on affected individuals. Although Exposure and Response Prevention (ERP) is widely regarded as the first-line intervention, its inherently distressing nature contributes to treatment refusal and premature dropout in a subset of patients. The present study aims to develop and validate a novel intervention, Mindfulness-Based Exposure Therapy (MBET). In contrast to existing protocols that incorporate mindfulness as an adjunct to ERP and have yielded mixed or limited benefits, this study seeks a theoretically grounded integration of mindfulness and exposure-based principles. We hypothesize that mindfulness training improves emotion regulation, thereby producing a synergistic effect that enhances patients' capacity to engage in and complete exposure tasks. From a clinical perspective, MBET is intended to offer a more tolerable and acceptable alternative to standard ERP, with the potential to improve treatment adherence and clinical outcomes among patients who experience traditional exposure procedures as excessively distressing.

Key facts

Study ID

NCT07484750

Run by

Shanghai Mental Health Center

People needed

64

Starts

2026-02-03

Expected to finish

2029-06-30

Last updated by the study team

2026-03-20

Who can join

Age: 16 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a primary diagnosis of Obsessive-Compulsive Disorder (OCD) according to DSM-5 criteria
• Are between 16 and 55 years of age (inclusive)
• Have a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score ≥ 16
• Have an education level of junior high school or above
• Are medication-free or have been stabilized on psychotropic medication for at least 8 weeks
• Have sufficient visual and auditory capabilities to complete study assessments
• Are willing to participate and provide written informed consent

You may not qualify if…

• Meet DSM-5 criteria for any other psychiatric disorder besides OCD
• Have severe OCD symptoms that prevent completion of assessments
• Exhibit active suicidal ideation or high suicide risk
• Have a serious somatic disease, central nervous system disease, or substance abuse history
• Are pregnant, breastfeeding, or planning pregnancy
• Have metal implants contraindicated for MRI (e.g., pacemakers, intracranial clips, metal dentures, arterial stents, joint fixations)

Where it is running

• Shanghai mental health center — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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