A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324
Completed · Phase 1
Conditions studied: Diabetic Macular Edema (DME), Neovascular (Wet) Age-Related Macular Degeneration
In brief
A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324
Key facts
- Study ID
- NCT07484074
- Run by
- Ollin Biosciences, Inc.
- People needed
- 164
- Starts
- 2025-02-12
- Expected to finish
- 2025-12-09
- Last updated by the study team
- 2026-03-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Be willing and able to understand the study procedures and the risks involved and provide written informed consent before the first study-related activity
- DME patients must be ≥ 18 years of age, nAMD patients must be ≥ 50 years of age
- Diagnosis of either DME or nAMD. nAMD patients must be treatment naïve. DME patients can be either treatment naïve or treatment experienced
- DME patients must have best corrected visual acuity of 78 to 25 letters
- nAMD patients must have best corrected visual acuity of 80 to 25 letters
You may not qualify if…
- If pregnant or breastfeeding
- History of cataract surgery and/or Yttrium-Aluminum Garnet (YAG) for removal of posterior capsular opacification (PCO) within 90 days
Where it is running
- Phoenix, AZ — Phoenix, Arizona, United States
- Glendale, CA — Glendale, California, United States
- Pasadena, CA — Pasadena, California, United States
- Sacramento, CA — Sacramento, California, United States
- Walnut Creek, CA — Walnut Creek, California, United States
- Waterford, CT — Waterford, Connecticut, United States
- Fort Myers, FL — Fort Myers, Florida, United States
- Saint Petersburg, FL — St. Petersburg, Florida, United States
- Winter Haven, FL — Winter Haven, Florida, United States
- Oak Forest, IL — Oak Forest, Illinois, United States
- Hagerstown, MD — Hagerstown, Maryland, United States
- Grand Rapids, MI — Grand Rapids, Michigan, United States
- Reno, NV — Reno, Nevada, United States
- Wake Forest, NC — Wake Forest, North Carolina, United States
- Tulsa, OK — Tulsa, Oklahoma, United States
- Springfield, OR — Springfield, Oregon, United States
- Germantown, TN — Germantown, Tennessee, United States
- Abilene, TX — Abilene, Texas, United States
- Arlington, TX — Arlington, Texas, United States
- Austin, TX — Austin, Texas, United States
- Bellaire, TX — Bellaire, Texas, United States
- Dallas, TX — Dallas, Texas, United States
- Katy, TX — Katy, Texas, United States
- Plano, TX — Plano, Texas, United States
- Round Rock, TX — Round Rock, Texas, United States
Full record on ClinicalTrials.gov
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