Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
Recruiting now · Not applicable
Conditions studied: Septic Shock
In brief
Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle impairment. In the intensive care setting, quantitative and qualitative assessment of muscle function is challenging due to critical care environments (general anesthesia, altered consciousness, etc.). CT scan measurement at the 3rd lumbar level has been proposed to evaluate muscle function. Recent retrospective studies have highlighted increased mortality among patients with muscle mass impairment and/or decreased muscle density.
Key facts
- Study ID
- NCT07483710
- Run by
- Centre Hospitalier Universitaire de Saint Etienne
- People needed
- 196
- Starts
- 2026-03-19
- Expected to finish
- 2030-05-01
- Last updated by the study team
- 2026-07-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients hospitalized in intensive care for septic shock defined by the presence of a documented or suspected infection, plasma lactate >2 mmol/L, and an increase in SOFA score of more than 2 points from baseline (Singer et al., 2016)
- Patients who underwent a non-contrast CT scan within 48 hours prior to admission and up to 24 hours after admission to intensive care
- Patients affiliated with or eligible for social security
You may not qualify if…
- Patients with a neuromuscular disease prior to admission to intensive care.
- Pregnant women
- Patients under guardianship and/or conservatorship
- Refusal of consent.
Where it is running
- Centre Hospitalier Universitaire de Saint-Etienne — Saint-Etienne, France (enrolling)
- Hospices Civils de Lyon — Lyon, France
- AP HM, Hôpital La Timone — Marseille, France
- Clinique Mutualiste — Saint-Etienne, France
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.