Effectiveness of Thoracoabdominal Nerve Block (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy

Recruiting now · Not applicable

Conditions studied: Postoperative Pain, Hysterectomy, Plane Blocks

In brief

This study aims to investigate the effectiveness of a specific regional anesthesia technique, the Modified-Thoracoabdominal Nerve Block through a Perichondrial Approach (M-TAPA), on reducing pain after laparoscopic hysterectomy surgery. Hysterectomy is a common major surgical procedure, and managing postoperative pain is crucial for patient comfort and faster recovery. Participants will be randomly assigned to one of two groups: The M-TAPA Group: Patients will receive the nerve block using a local anesthetic (bupivacaine) before the surgery begins. The Control Group: Patients will receive standard postoperative pain management without the nerve block. The primary goal is to determine if the M-TAPA block reduces the total amount of opioid (morphine) used by patients in the first 24 hours after surgery. The researchers will also evaluate pain scores (NRS), the time until the first request for additional pain medication, patient satisfaction, and any side effects like nausea or vomiting

Key facts

Study ID

NCT07483190

Run by

Istinye University

People needed

60

Starts

2026-06-09

Expected to finish

2026-11-15

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older, up to 70. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Aged between 18 and 70 years
• ASA (American Society of Anesthesiologists) physical status I, II, or III
• Scheduled for elective laparoscopic hysterectomy
• Voluntary participation with signed informed consent

You may not qualify if…

• Hepatic or renal disease.
• Coagulation disorders.
• Uncontrolled cardiovascular or respiratory diseases.
• Psychiatric disorders.
• History of allergy to local anesthetics.
• History of alcoholism, drug or substance abuse.
• Body Mass Index (BMI) greater than 35 kg/m2
• Refusal of the regional block procedure

Where it is running

• Istinye University Liv Hospital Bahcesehir — Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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