A Study Of T1/Tref Intubating Conditions

Enrolling by invitation · Not applicable

Conditions studied: Intubation

In brief

The purpose of this study is to determine the maximum ratio of the twitch amplitude (T1) to the reference twitch (Tref) amplitude (T1/Tref) that provides excellent intubating conditions.

Key facts

Study ID

NCT07483164

Run by

Mayo Clinic

People needed

108

Starts

2026-08-31

Expected to finish

2026-12-31

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > or = 18 years old
• Patients willing to participate and provide an integrated, informed consent

You may not qualify if…

• Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
• Patients with systemic neuromuscular diseases such as myasthenia gravis.
• Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents, i.e., severe renal impairment requiring dialysis or end-stage liver disease.
• Patients requiring a rapid sequence induction for airway protection.
• Patients deemed ineligible for surgery, including pregnancy (as determined by standard of care testing).

Where it is running

• Mayo Clinic in Florida — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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