Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)

Recruiting now

Conditions studied: Gastro Esophageal Reflux

In brief

This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic. Participants are recruited through schools and complete a web-based questionnaire assessing reflux-related symptoms. Children reporting pyrosis or regurgitation undergo a stepwise diagnostic evaluation that includes a standardized proton pump inhibitor (PPI) trial, upper endoscopy when indicated, and 24-hour pH-impedance monitoring for those with inconclusive findings. These procedures allow classification into confirmed GERD, reflux hypersensitivity, or functional pyrosis. All children undergoing diagnostic testing complete a validated quality-of-life questionnaire. The study will provide population-based prevalence estimates and evaluate symptom burden and potential risk factors associated with pediatric GERD.

Key facts

Study ID

NCT07482969

Run by

University Hospital, Motol

People needed

1000

Starts

2025-12-20

Expected to finish

2028-12-30

Last updated by the study team

2026-03-19

Who can join

Age: 8 and older, up to 13. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age group of 8 - 9 years and 12 - 13 years
• school attendance ability

You may not qualify if…

• psychomotor impairment

Where it is running

• Motol University Hospital — Prague, Czechia (enrolling)

Full record on ClinicalTrials.gov

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