A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Obesity, Knee Osteoarthritis (OA)
In brief
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Key facts
- Study ID
- NCT07481630
- Run by
- Novo Nordisk A/S
- People needed
- 400
- Starts
- 2026-04-13
- Expected to finish
- 2028-08-14
- Last updated by the study team
- 2026-07-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Glycated haemoglobin more than or equal to (≥) 6.5% [(48 millimoles per mole (mmol/mol)] as measured by the central laboratory at screening.
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.
- Any joint prosthesis or joint replacement in target knee.
- Arthroscopy or injections into target knee within the last 90 days prior to screening.
- Any other joint disease in target knee including gout and pseudogout.
Where it is running
- Diablo Clinical Research, Inc. — Walnut Creek, California, United States (enrolling)
- Chase Medical Research LLC — Hamden, Connecticut, United States (enrolling)
- Chase Medical Research LLC — Waterbury, Connecticut, United States (enrolling)
- Zenith clinical research — Hollywood, Florida, United States (enrolling)
- CNS Healthcare — Jacksonville, Florida, United States (enrolling)
- Angels Clinical Research Institute — Miami Lakes, Florida, United States (enrolling)
- Hope Clin Res & Wellness — Conyers, Georgia, United States (enrolling)
- CenExel iResearch, LLC — Decatur, Georgia, United States (enrolling)
- Elite Clinical Trials — Blackfoot, Idaho, United States (enrolling)
- MedVadis Research Watertown — Waltham, Massachusetts, United States (enrolling)
- Jubilee Clinical Research, Inc. — Las Vegas, Nevada, United States (enrolling)
- Great Lakes Medical Research — Westfield, New York, United States (enrolling)
- Accellacare and KDCILM, LLC — Wilmington, North Carolina, United States (enrolling)
- Coastal Carolina Res Ctr — North Charleston, South Carolina, United States (enrolling)
- VIP Trials_San Antonio — San Antonio, Texas, United States (enrolling)
- Charlottesville Med Research — Charlottesville, Virginia, United States (enrolling)
- Health Res of Hampton Roads — Newport News, Virginia, United States (enrolling)
- Northwest Clinical Research Center — Bellevue, Washington, United States (enrolling)
- Emeritus Research Sydney — Botany, New South Wales, Australia (enrolling)
- Momentum Clinical Research Darlinghurst — Darlinghurst, New South Wales, Australia (enrolling)
- Kolling Institute — St Leonards, New South Wales, Australia (enrolling)
- Heart of Australia — Chelmer, Queensland, Australia (enrolling)
- Coastal Digestive Health — Maroochydore, Queensland, Australia (enrolling)
- UMHAT Sveti Georgi EAD, Plovdiv — Plovdiv, Bulgaria (enrolling)
- Arizona Research Center, Inc. — Phoenix, Arizona, United States (enrolling)
Full record on ClinicalTrials.gov
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