Personalized Mobile Reminders for Medication Adherence and Intraocular Pressure Control in Primary Open-Angle Glaucoma
Starting soon · Not applicable
Conditions studied: Primary Open-Angle Glaucoma (POAG)
In brief
This study evaluates whether a personalized mobile reminder program improves treatment adherence and clinical outcomes in adults with primary open-angle glaucoma (POAG) using topical antiglaucoma eye drops. Poor adherence to long-term eye-drop therapy is common in glaucoma care and may contribute to inadequate intraocular pressure (IOP) control and disease progression. Participants are randomized to either (1) a digital adherence intervention or (2) standard outpatient follow-up. The intervention consists of daily interactive SMS/WhatsApp medication reminders plus weekly brief educational messages for 3 months. The primary outcome is change in medication adherence measured by the Morisky Medication Adherence Scale-8 (MMAS-8) at month 3. Secondary outcomes include change in IOP, eye-drop instillation technique, and treatment satisfaction. Exploratory analyses assess the relationship between adherence level and OCT-based retinal nerve fiber layer (RNFL) progression metrics. The goal is to determine whether a low-cost, scalable mobile strategy can improve short-term glaucoma management in routine practice.
Key facts
- Study ID
- NCT07480577
- Run by
- Sakarya Yenikent State Hospital
- People needed
- 84
- Starts
- 2026-04-01
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2026-03-18
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 to 75 years. Diagnosis of primary open-angle glaucoma (POAG) in at least one eye. Currently treated with at least one topical antiglaucoma medication. Able to read and understand study procedures and provide written informed consent.
- Has regular access to a mobile phone capable of receiving SMS or WhatsApp messages.
- Willing to comply with follow-up visits and study procedures for 3 month
You may not qualify if…
- Secondary glaucoma (e.g., neovascular, uveitic, steroid-induced) or angle-closure glaucoma.
- Ocular surgery or laser procedure within the previous 3 months, or planned ocular surgery during study follow-up.
- Advanced ocular comorbidity likely to affect IOP assessment or adherence evaluation (e.g., severe corneal disease, active ocular infection/inflammation).
- Cognitive impairment, severe psychiatric disease, or communication barriers that prevent reliable participation.
- Inability to use or access mobile messaging tools required for the intervention.
- Participation in another interventional clinical study that may interfere with outcomes
Full record on ClinicalTrials.gov
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