5-Year Postoperative Outcomes of Patients Who Completed the CREST Study

Enrolling by invitation

Conditions studied: Open-angle Glaucoma (OAG)

In brief

This study is designed to collect clinical data at 3, 4, and 5 years postoperatively for participants who completed the CREST Study without having secondary IOP-lowering surgery in the study eye(s).

Key facts

Study ID

NCT07480343

Run by

Iantrek, Inc.

People needed

250

Starts

2025-09-15

Expected to finish

2030-12-01

Last updated by the study team

2026-07-21

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of open-angle glaucoma (OAG) in the study eye(s), including pigmentary and pseudoexfoliative glaucoma, at the time of CREST enrollment
• Completed participation in CREST
• Provide signed written consent using the Institutional Review Board (IRB)/Ethics Committee (EC) approved study-specific informed consent form (ICF)
• Ability, comprehension, and willingness to follow study instructions

You may not qualify if…

• Systemic disease that, in the opinion of the Investigator, would put participant's health at risk and/or prevent completion of required study visits
• Early termination from CREST
• Secondary surgical intervention for long-term IOP control in the study eye(s)

Where it is running

• CREST-XT Site 05 — Newport Beach, California, United States
• CREST-XT Site 03 — Cape Coral, Florida, United States
• CREST-XT Site 10 — DeLand, Florida, United States
• CREST-XT Site 07 — Atlanta, Georgia, United States
• CREST-XT Site 12 — Chevy Chase, Maryland, United States
• CREST-XT Site 13 — Rockville, Maryland, United States
• CREST-XT Site 16 — Las Vegas, Nevada, United States
• CREST-XT Site 01 — Fort Washington, Pennsylvania, United States
• CREST-XT Site 04 — Crossville, Tennessee, United States
• CREST-XT Site 11 — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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